Bloemfontein is the capital city of the Free State Province of South Africa as well as one of the nation's three capitals, the judicial capital. The city's Sesotho name is Mangaung, meaning "place of cheetahs" and became part of the Mangaung Local Municipality in 2000. Bloemfontein is popularly and poetically known as "the city of roses", owing to the abundance of these flowers and the annual rose festival held there The city is home to 369,568 residents, while the Mangaung Local Municipality has a population of 645,455. Bloemfontein is served by Bloemfontein airport.

Cape Town is the second most populous city in South Africa, forming part of the metropolitan municipality of the City of Cape Town. It is the provincial capital of the Western Cape, as well as the legislative capital of South Africa, where the National Parliament and many government offices are situated. Cape Town is famous for its harbour as well as its natural setting in the Cape floral kingdom, including such well-known landmarks as Table Mountain and Cape Point. Cape Town is Africa's most popular destination for tourism. Located on the shore of Table Bay, Cape Town was originally developed by the Dutch East India Company as a victualling (supply) station for Dutch ships sailing to Eastern Africa, India, and the Far East. Jan van Riebeeck's arrival on 6 April 1652 established the first permanent European settlement in South Africa. Cape Town quickly outgrew its original purpose as the first European outpost at the Castle of Good Hope, becoming the economic and cultural hub of the Cape Colony. Until the Witwatersrand Gold Rush and the development of Johannesburg, Cape Town was the largest city in South Africa. As of 2007 the city had an estimated population of 3.5 million. Cape Town's land area of 2,455 square kilometres (948 sq mi) is larger than other South African cities, resulting in a comparatively lower population density of 1,425 inhabitants per square kilometre (3,690 /sq mi).

Johannesburg is the largest city in South Africa. Johannesburg is the provincial capital of Gauteng, the wealthiest province in South Africa, having the largest economy of any metropolitan region in Sub-Saharan Africa. The city is one of the 40 largest metropolitan areas in the world and it is one of Africa's only three global cities, the other two being Cairo and Cape Town. While Johannesburg is not officially one of South Africa's three capital cities, it does house the Constitutional Court – South Africa's highest court. Johannesburg is the source of a large-scale gold and diamond trade, due to its location on the mineral-rich Witwatersrand range of hills. Johannesburg is served by O.R. Tambo International Airport, the largest and busiest airport in Africa and a gateway for international air travel to and from the rest of southern Africa. According to the 2007 Community Survey, the population of the municipal city was 3,888,180 and the population of the Greater Johannesburg Metropolitan Area was 7,151,447. A broader definition of the Johannesburg metropolitan area, including the Ekhuruleni, the West Rand, Soweto and Lenasia, has a population of 10,267,700. The municipal city's land area of 1,645 km2 (635 sq mi) is very large when compared to other cities, resulting in a moderate population density of 2,364 /km2 (6,120 /sq mi).